Our review on the different functions of RKIP on tumor cells and the heart has been published.
The RAF Kinase Inhibitor Protein has a dual inhibitory function, it inhibits not only the RAF-MAPK pathway, but also the G-protein coupled receptor kinase 2 (GRK2). Consequently, the effects of RKIP on tumor cells and the heart are different: RKIP inhibits tumor growth but RKIP is detrimental for the heart, as found in the Quitterer lab. Our in-depth review explains the different functions of RKIP in tumor cells and in cardiomyocytes, and discusses mechanisms triggered by RKIP as a tumor growth inhibitor and as a GRK2 inhibitor.
The abstract of this review can be found here: external pagehttps://pubmed.ncbi.nlm.nih.gov/35203304/
Read the article which has been published in the MDPI journal external pageCells here: external pagehttps://www.mdpi.com/2073-4409/11/4/654