Top 2% of more than 6600 articles per year
A recent study identified a novel treatment approach for symptoms of end-stage heart failure, which was selected as paper of the week in the "Journal of Biological Chemistry".
Treatment approach for failing hearts
In Switzerland more than 120 000 patients are suffering from heart failure. With increasing life expectancy, the number is increasing world-wide. End-stage heart failure has a worse prognosis than most malignancies and new treatment options are urgently needed.
In frame of our research we found a novel approach, which targets symptoms of end-stage heart failure and interrupts the vicious cycle of oxygen depletion, heart muscle damage and inefficient energy generation. The treatment approach relies on inhibition of the G-protein-coupled receptor kinase 2 (GRK2) and improves the inefficient energy generation and cardiac performance of a failing heart.
The findings are published in the "Journal of Biological Chemistry" on February 5, 2016. The editors selected the article as "Paper of the Week". This means that the work is among the Top 2 % of more than 6600 articles published per year in the Journal of Biological Chemistry.
